LYMPHOID NEOPLASIA NK314 potentiates antitumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase II and DNA-dependent protein kinase
نویسندگان
چکیده
1Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan; 2Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Tottori Japan; 3Pharmaceutical Research Laboratories, Nippon Kayaku Co, Ltd, Tokyo, Japan; and 4Department of Transfusion Medicine, Saga University Hospital, Saga, Japan
منابع مشابه
DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor.
4-Hydroxy-5-methoxy-2,3-dihydro-1H-[1,3]benzodioxolo[5,6-c]pyrrolo[1,2-f]-phenanthridium chloride (NK314) is a benzo[c] phenanthridine alkaloid that inhibits topoisomerase IIα, leading to the generation of DNA double-strand breaks (DSBs) and activating the G(2) checkpoint pathway. The purpose of the present studies was to investigate the DNA intercalating properties of NK314, to evaluate the DN...
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